How Applied Neuroscience, Inc.
Has Changed the Face of EEG Biofeedback

1994 –  First to Introduce and Implement a Normative Database to EEG Biofeedback (Lexicor).  The goal was to use Z Scores from Norms for Assessment, Biofeedback Protocol Development & Evaluation of Treatment efficacy following Biofeedback.

2000 -   First to publish how to compute LORETA Z scores in real-time for Neurofeedback.

2002 –  First to Produce Commercial Software that Integrates Conventional EEG with QEEG on the Same Screen at the Same Time.

2004  –  First to Implement Live Z Scores (real-time) for EEG Biofeedback.

2005  –  First to Implement LORETA Source Correlations.

2008  –  First to Implement 19 Channel EEG Z Score Biofeedback.

              First to Implement Surface EEG Phase Shift & Phase Lock measures   

              First to Implement Cross-Frequency Phase Lock & Phase Shift Duration.

              First to Implement LORETA Z Score Biofeedback.

2009  –  First to Implement Seamless Integration of QEEG Assessment and Biofeedback

              First to Implement Surface Laplacian EEG Biofeedback.

              First to Implement Average Reference EEG Biofeedback.

              First to Implement a Symptom Check List to produce Biofeedback protocols of
the Surface EEG.

2010  –  First to Implement a Symptom Check List with LORETA Z score Biofeedback.

2011  –  First to implement LORETA Coherence and Phase Z Score Biofeedback

2012  –  First to Implement LORETA Coherence and Phase Difference in Biofeedback.

              First to Produce the “Handbook of QEEG and EEG Biofeedback” a Textbook for Students and Professionals.

2013  –  First to Implement LORETA Z Scores of Phase Lock & Phase Shift
to  Biofeedback.

             First to Implement a Real-Time 3D Rendered MRI volume & Nodes (Brodmann Areas) and Connections (Coherence, Phase and Phase Reset) between Nodes for Assessment and Biofeedback. The new “BrainSurfer”                                    

2014 –  First to Implement LORETA Phase Shift and Phase Lock Duration Z Scores for
             Assessment with Color Coded Contour Maps

             First to Implement an Automatic Clinical Report Writer that is Generated Locally
             to Empower Individual Clinicians, thus Removing the need for an External QEEG
             Report Services.

2015 –  First to Implement NeuroLink to allow patients/clients to assess symptom severity and seamlessly select a protocol to reinforce stability in dysregulated brain networks linked to the symptoms

                  First to implement a Neural Network Injury Index of patients/clients following a concussion and TBI

               First to integrate a Chinese amplifier (Fistar SNS) for real-time EEG Z score Biofeedback

                 First to implement Effective Connectivity or measures of information flow between all combinations of 19 EEG channels using the Phase Slope Inde (PSI) for assessment

               First to implement Effective Connectivity or measures of information flow between all combinations of 88 Brodmann Areas using LORETA with the Phase Slope Index (PSI) for assessment

 2016-   First to compute Z scores for swLORETA with 12,270 voxels and a real MRI to replace the Key Institute LORETA  and sLORETA

              First to implement a "Concussion Index" to track brain network changes over time and following treatment

              First to implement the BrainSurfer Viewer to allow one to explore 3-Dimensional Z score connectivity

2017-     First to implement the "Brain Function Index" using funcional and effective connectivity Z score metrics with sLORETA to track changes in brain networks in the direction of optimal functioning

              First to implement Phase/Amplitude Coupling with Z scores for surface and between Brodmann areas

              First to implement Cross-Frequency Coherence with Z scores

More Innovations in Preparation… (swLORETA, Effective Connectivity of 1 to 19 channel scalp surface Neurofeedback, Effective Connectivity of LORETA Neurofeedback, NeuroLink expansions, ACR updates, Phase/Amplitude Cross-Frequency add ons, more visual and auditory feedback methods, ……. etc.)